1st Best Practice Example of Personalised Medicine Research & Implementation - From Basic Research to the Patient

Network Genomic Medicine in Germany - Implementing Personalised Lung Cancer Care in Clinical Routine

Introduction and Moderation: Jürgen Wolf, University Hospital Cologne, Germany

The genomic approach: Roman Thomas, University of Cologne, Germany
High-end molecular diagnostics: Reinhard Büttner, University Hospital Cologne, Germany
Innovative clinical trials: Sebastian Michels, University Hospital Cologne, Germany
Data management & IT strategy: Jürgen Wolf, University Hospital Cologne, Germany
Organization of the network: Anna Kron, University Hospital Cologne, Germany
The referring doctor's perspective: Achim Rothe, Medical Oncologist,  Germany
The patient's perspective: Bärbel Söhlke, Patient, Germany
The payer's perspective: Gerhard Schillinger, AOK Bundesverband, Germany


Jürgen Wolf

University Hospital Cologne, Germany

Jürgen Wolf, MD, is currently Medical Director of the Center for Integrated Oncology (CIO) at the University Hospital Cologne. He holds a professorship for Interdisciplinary Translational Oncology at the University of Cologne and is speaker of the CIO lung cancer program.

Prof. Wolf received his MD degree from the University of Freiburg. He spent his postdoctoral fellowship at the German Cancer Research Center Heidelberg (1986-1990). In 1990 he started his clinical training in the Department of Internal Medicine, University Hospital of Cologne. He headed the Laboratory for Research on Hodgkin´s Lymphoma in Cologne (1990-2003)  and was co-chairman of the German Hodgkin´s Lymphoma Study Group (2000-2004). From 2004 he coordinated the establishment of the Center for Integrated Oncology (CIO) at the University Hospital of Cologne. In 2005 he initiated the lung cancer program in the CIO and founded the Lung Cancer Group Cologne. In 2010 he co-founded the Network Genomic Medicine (NGM) Lung Cancer, a health care provider network integrating now more than 250 centers in Germany for centralized next-generation-sequencing based molecular genotyping and allocation of patients to personalized treatment in and outside clinical trials. For foundation of the Network Genomic Medicine he received the Innovation Award of the state of North Rhine-Westphalia in 2016 and has been Speaker of the national Netword Genomic (nNGM) Lung Cancer funded by the German Cancer Aid since 2018.

Roman Thomas

University Hospital Cologne, Germany




Reinhard Büttner

University Hospital Cologne, Germany

Reinhard Büttner is Professor and Chairman of The Institute of Pathology at University Hospital Cologne, Köln, Germany, and the Co-Founder and Chief Scientific Officer of TARGOS Molecular Diagnostics. He completed his medical degree at the University of Mainz, Mainz, Germany, in 1985, before starting a residency at Rheinisch-Westfalische Technische Hochschule RWTH Aachen, Aachen, Germany. In 1987, he began post-doctoral work at the Gene Centre Munich and MD Anderson Cancer Centre, Houston, TX, USA (1987‒1990). Returning to Germany in 1991, he took up a residency at the University of Regensburg, before becoming Professor and Chairman for Pathology at RWTH Aachen (1999‒2001). After which, he worked as a Professor and Chairman of Pathology at the University of Bonn (2001‒2011), before being appointed to his current position as Professor and Chairman of Pathology at the University of Cologne in 2011.

Reinhard Büttner specialises in molecular pathology and is a member of a number of academic societies including the German Society of Pathology and the International Academy of Pathology. He is the Co-President of the International Academy of Pathology World Congress of Pathology, Cologne 2016. He has more than 450 peer-reviewed papers published in high-impact internationally renowned journals.

Sebastian Michels

University Hospital Cologne, Germany

Sebastian Michels is subinvestigator at the Lung Cancer Group Cologne (Germany) and resident in medical oncology and hematology at the University of Cologne. Michels is medical coordinator of EATON, a phase I trial with EGF816 and Trametinib in EGFR T790M-positive NSCLC, and EUCROSS, a phase II trial to evaluate efficacy and safety of crizotinib in advanced adenocarcinoma oft he lung harbouring ROS1 translocations.

Anna Kron

University Hospital Cologne, Germany

Anna Kron ist the Head of Business Unit of the national Network Genomic Medicine Lung Cancer at the University Hospital Cologne in Germany. The network strives to offer comprehensive and high-quality molecular diagnostics for all patients with lung cancer and thus to promote the implementation of personalised therapy in routine clinical care. Anna has a background in health economics and specialized in clinical trials and evidence based medicine. Before coming to the national Network Genomic Medicine Lung Cancer, Anna served as the Head of Financial Management and Controlling at the ClinicalTrial Unit at the University Hospital Cologne.

Achim Rothe

Medical Oncologist, Germany




Bärbel Söhlke

Patient, Germany

Bärbel Söhlke is a mathematician and has worked in corporate finance, business controlling and system development in the chemical industry. She was diagnosed with advanced lung cancer at the age of 50. She experienced various treatments and repeated relapses until comprehensive molecular diagnostics were performed by the lung cancer group Cologne. Her tumor was found to harbor the rare ROS1 translocation. Subsequent targeted therapy resulted in significant clinical improvements and a complete tumor remission for six years to date. Bärbel is engaged in a global group of more than 300 patients and caregivers in 30 countries dealing with ROS1-positive cancer that strives to increase awareness and education, accelerate research, and improve access to effective diagnosis and treatment.

Gerhard Schillinger

AOK Bundesverband, Germany




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