The introduction of personalised medicine, through the increasing multi-omics characterization of disease, brings new challenges to disease modeling.
The scope of the PERMIT review was a broad evaluation of the relevance, validity, and predictive value of the current preclinical methodologies applied in stratified medicine approaches.
Two case models were chosen: oncology and brain disorders. Relevant publication databases were searched for preclinical models applied in personalised medicine approaches. The report identifies underlying gaps in preclinical research relating to the relevance of experimental models, quality assessment practices, reporting, regulation, and a gap between preclinical and clinical research.
The report is available here: